Association between accelerated biological aging and colorectal cancer: a cross-sectional study.

ABSTRACT:

Background

Biological age (BA) is regarded as a more accurate marker of aging than chronological age and is commonly used to assess associations with age-related diseases. The relationship between BA measures and the colorectal cancer (CRC) has not yet been investigated.

Methods

This study utilized data from the National Health and Nutrition Examination Survey. BA was quantified using the Klemera-Doubal method age (KDMAge) and phenotypic age (PhenoAge), based on 13 common clinical biomarkers. The prevalence of CRC across quartiles of BA indicators was compared using weighted Chi-square tests. Weighted multivariable logistic regression models were used to assess the association between BA indicators and CRC.

Results

A total of 36,684 participants were included. The wei

SUBMITTER: Wang S 

PROVIDER: S-EPMC11885229 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature