Impaired immune reconstitution in HIV infection: the role of CD4⁺ T-cell-associated NKG2D ligands, CD4⁺ T-cell subsets imbalance, and immune function deficiency.

ABSTRACT:

Objective

The role of natural killer (NK) cells, which mediate innate immunity, in the immune reconstitution of people living with HIV (PLWH) remains unclear. Our previous research indicated that early activation of CD56^dimCD16^dim/- NK cells plays an important role in the recovery of CD4⁺ T cells in immunological non-responders (INRs) after ART. This study mainly focuses on the profiles of cell receptors and their relative ligands for NK cells and CD4⁺ T cells exhibited on INRs and immunological responders (IRs) in order to analyze the impact of differential immune status on immune reconstitution in PLWH receiving ART.

Methods

This study included 66 PLWH who had been on ART for 4 years, comprising 32 INRs and 34 IRs. Using flow cyt

SUBMITTER: Xu Q 

PROVIDER: S-EPMC11885256 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature