Abnormal static and dynamic functional connectivity of striatal subregions in patients with obsessive-compulsive disorder.

ABSTRACT:

Background

As a crucial node of the cortico-striato-thalamo-cortical (CSTC) loop, the striatum has long been considered to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Numerous neuroimaging studies have reported functional abnormalities of the striatum in OCD. However, altered dynamic functional connectivity (DFC) patterns of striatal subregions were rarely reported in patients with OCD.

Methods

We collected resting-state functional MRI data from 97 first episode and drug-naïve OCD patients and 106 HCs matched for gender and age. Seed-based whole-brain resting-state functional connectivity (RSFC) and DFC analysis were performed for 12 striatal subregions. Between-group differences of the mean RSFC and DFC were determined using a two-sample t-tes

SUBMITTER: Shi W 

PROVIDER: S-EPMC11885261 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature