Detection of hemodynamic changes in a porcine lipopolysaccharide model of systemic inflammation using dynamic light scattering measurements of the microcirculation.

ABSTRACT:

Background

The microcirculation is affected during sepsis, yet there is currently no clinically available technology for sepsis detection in the microcirculation. This study aimed to detect microcirculatory changes using a dynamic light scattering (DLS) skin sensor during an endotoxic shock with a systemic inflammatory response in a porcine lipopolysaccharide (LPS) model.

Methods

Thirty female Yorkshire x Norwegian Landrace pigs were divided into three groups: control, LPS, and LPS with resuscitation. After baseline measurements, LPS (1.75 μg∙kg^-1∙h^-1) was administered in progressively increasing dosages in the LPS and resuscitation groups. Two mDLS™ sensors, placed centrally and peripherally, measured total blood flow (TBF), relative blood velocity (RB

SUBMITTER: Te Nijenhuis LH 

PROVIDER: S-EPMC11885275 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature