Sex-dependent alterations of colonic epithelial permeability: relevance to irritable bowel syndrome.

ABSTRACT:

Introduction

Increased intestinal permeability is a possible pathophysiological mechanism of irritable bowel syndrome (IBS). Increased colonic epithelial permeability is associated with visceral nociception in rodents and abdominal pain severity in IBS patients. Although IBS is more common in women, most studies on IBS-associated epithelial dysfunction have largely overlooked sex as a biologic variable.

Methods

Men and women with Rome III- and Rome IV-positive IBS and HCs rated GI symptoms including abdominal pain severity at baseline, 24 h prior and immediately post procedure. Epithelial function was assessed ex vivo in Ussing chambers using sigmoid colon biopsies, by monitoring short-circuit current (Isc), transepithelial electrical resistance (TEER) and mucosal per

SUBMITTER: Larauche M 

PROVIDER: S-EPMC11885305 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature