Cxcl9-deficiency attenuates the progression of post-traumatic osteoarthritis in mice.

ABSTRACT:

Objective

Osteoarthritis (OA) is one of the leading causes of disability in the aging population. While about 10% of the adult population is affected by OA, there is to date no curative treatment and joint replacement surgery remains the only option for treating end-stage OA. Previous studies found elevated levels of the chemokine C-X-C motif ligand 9 (CXCL9) in the synovial fluid of OA knees. However, the exact role of CXCL9 in OA progression is still unknown.

Methods

Female wild-type and Cxcl9-deficient mice were challenged with a unilateral anterior cruciate ligament transection (ACLT). Joint destruction in early and late stages of experimental OA was assessed using micro-CT scanning, histological scoring, histomorphometry, and gene expression analysis.

Results

Ina

SUBMITTER: Donat A 

PROVIDER: S-EPMC11885341 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature