Fecal microbiome composition in neonates with or without urinary tract infection.

ABSTRACT:

Background

Most infants with febrile urinary tract infection (UTI) do not have an underlying anatomical risk factor. Thus, other non-anatomical risk factors should be considered. Since the most common pathogens arise from the fecal microbiota, our aim was to investigate whether the gut microbiota composition differs between febrile infants younger than 2 months with or without UTI.

Methods

In this prospective, case-control, pilot study, we performed 16S ribosomal ribonucleic acid amplicon sequencing to characterize gut microbiota of febrile neonates with and without UTI admitted to the pediatric ward at Shamir Medical Center between February 2019 and May 2021.

Results

The study cohort included 42 febrile neonates: 17 with and 25 without febrile UTI. We found a signifi

SUBMITTER: Bahat H 

PROVIDER: S-EPMC11885367 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature