Tau levels in platelets isolated from Huntington's disease patients serve as a biomarker of disease severity.

ABSTRACT: Tau is a microtubule protein that is known to be hyperphosphorylated and to aggregate in several chronic neurodegenerative disorders. In many cases, in particular in Alzheimer's disease, the degree of tau pathology has been demonstrated to correlate with cognitive deficits and/or decline. In Huntington's disease (HD), a dominantly inherited neurodegenerative disorder, both cognitive impairments and abnormal tau expression have been reported to occur, along with the accumulation of the mutant huntingtin protein. In this respect, tau has been shown to be present in the cerebrospinal fluid of individuals with HD and to increase with disease progression. However, how this relates to changes in tau found in the periphery is largely unknown. In this study, we collected blood samples from patient

SUBMITTER: Alpaugh M 

PROVIDER: S-EPMC11885373 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature