Adrenergic blockers, statins, and non-steroidal anti-inflammatory drugs are associated with later age at onset in Parkinson's disease.

ABSTRACT:

Background

Several factors have been shown to modify the risk of developing Parkinson's disease (PD), including commonly prescribed medications. However, there is little data describing their correlation with age at onset (AAO) of clinical symptoms. The objective of this study was to evaluate the association of treatment with anti-hypertensives, non-steroidal anti-inflammatories (NSAIDs), statins, as well as smoking and family history of PD with AAO in a large clinical cohort.

Methods

A retrospective review of 1201 initial encounters collected information on known risk-modulating factors for PD, including smoking status and family history, anti-hypertensives, statins, NSAIDs, anti-diabetic medications, and beta-agonists. In addition to general exposure, we determined whether

SUBMITTER: Malatt C 

PROVIDER: S-EPMC11885381 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature