Ecology of Gene Drives: The Role of Density-Dependent Feedbacks on the Efficacy and Dynamics of Two-Locus Underdominance Gene Drive Systems.

ABSTRACT: Density dependence describes the regulation of population growth rate by population density. This process is widely observed in insect populations, including vectors such as mosquitoes and agricultural pests that are targets of genetic biocontrol using gene drive technologies. While there continues to be rapid advancement in gene drive molecular design, most studies prioritise gene drive efficacy over ecology, and the role of density-dependent feedback on gene drives remains neglected. Furthermore, the details of density dependence experienced in these potential species of interest are usually poorly understood, creating additional constraints and challenges in evaluating the efficacy and efficiency of gene drive systems, especially those that promise local confinement after release. Here,

SUBMITTER: Xu Z 

PROVIDER: S-EPMC11885413 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature