Along-tract white matter abnormalities and their clinical associations in recent-onset and chronic schizophrenia.

ABSTRACT: Structural impairments in white matter tracts are well-documented in schizophrenia, though their clinical implications remain limited. Most previous studies using diffusion-weighted magnetic resonance imaging (dMRI) and tractography relied on averaged diffusion indices, potentially obscuring localized changes in white matter tracts. Tractometry enables the investigation of localized changes at specific points along white matter tracts. We used dMRI and centerline tractometry to examine along-tract white matter abnormalities in 55 patients with recent-onset schizophrenia, 69 with chronic schizophrenia, and 77 healthy controls. Fractional anisotropy (FA) and peak length were measured at individual points along tract trajectories. Group differences in diffusion indices and their associations

SUBMITTER: Joo SW 

PROVIDER: S-EPMC11885433 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature