Developmental and toxicological effects of butylated hydroxytoluene metabolites on zebrafish larvae.

ABSTRACT: Butylated hydroxytoluene (BHT) is among the most widely used synthetic phenolic antioxidants. However, BHT and its metabolites have been detected in aquatic ecosystems, posing potential risks to aquatic organisms. The present study aimed to investigate the effects of BHT metabolites on embryonic development in zebrafish. To this end, embryos were exposed to BHT metabolites, including 3,5-di-tert-butyl-4 hydroxybenzaldehyde (BHT-CHO), 2,6-di-tert-butyl-4-(hydroxymethyl) phenol (BHT-OH), 3,5-di-tert-butyl-4 hydroxybenzoic acid (BHT-COOH), 2,6-di-tert-butyl-P-benzoquinone (BHT-Q), and 2,6-di-tert-butyl-4-hydroxy-4-methylcyclohexa-2,5-dien-1-one (BHT-quinol), from 1-120 h post-fertilization (hpf). BHT-CHO, -OH, -COOH, -Q, and -quinol were toxic to zebrafish larvae with 96 h LC₅₀ val

SUBMITTER: Noh W 

PROVIDER: S-EPMC11885457 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature