Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code.

ABSTRACT: Multiple DNA damage resulting from different nearby ionizations of water molecules is an important process of the initial step of radiobiological effects. Several important characteristics of the damaged DNA site such as the critical size and types of chemical lesions are not well-known. We investigated this long-term issue by developing a dynamic Monte Carlo code for the chemical process. The reaction probabilities and the spatial distribution of lesions were theoretically solved as a function of the spur radius and distance between DNA and the initial ionisation position. From our previous reported results, we suggest that a hydroxyl radical and a hydrated electron from a single spur can concomitantly react within a 10 base pairs DNA to induce a multiple DNA damage site comprising a DNA

SUBMITTER: Kai T 

PROVIDER: S-EPMC11885462 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature