The CYP2D6 phenotyping performance of single-point saliva metabolic ratio in a healthy Chinese Han population.

ABSTRACT: The CYP2D6 plays critical roles in drug metabolism, and its inter-individual variability should be properly addressed in clinical practice. Our research aimed to assess the performance of single-point saliva metabolic ratio (MR) in a healthy Chinese Han population using dextromethorphan as the probe drug. MR was determined as the ratio of parent drug to metabolite in 3 h saliva, 3 h plasma, and 0-3 h urine post-ingestion. 416 healthy volunteers were enrolled, with 290 (69.7%) male participants and a median body mass index (BMI) of 23.1 kg/m². The Spearman correlation coefficients were 0.876 between plasma and saliva MR, and 0.746 between plasma and urine MR. The population was clustered into four metabolizer classes with either plasma or saliva MR, but into two metabolizer class

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11885511 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature