Subepicardial adipose genes contribute to the deterioration of heart failure preserved ejection fraction.

ABSTRACT:

Background

The mortality of patients with acute myocardial infarction (MI) raised rapidly in last decade and obesity are becoming the major cause to CAD progression, thus inducing heart failure preserved ejection fraction (HFpEF). However, why visceral adipocytes show different effects on healthy and ageing cardiomyocytes is less known.

Methods

GSE251971 was downloaded and Venn diagram between visceral adipocyte genes genes and DEGs was performed to obtain visceral adipocyte-associated DEGs in heart failure. Protein-protein interaction (PPI) network was constructed to obtain the hub genes utilizing the Cytoscape plugin Cytohubba. The hub genes and their interactions were analyzed using NetworkAnalyst 3.0 and for validation, the hub genes expressions were analyzed using Singl

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11885512 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature