An integrative phenotype-structured partial differential equation model for the population dynamics of epithelial-mesenchymal transition.

ABSTRACT: Phenotypic heterogeneity along the epithelial-mesenchymal (E-M) axis contributes to cancer metastasis and drug resistance. Recent experimental efforts have collated detailed time-course data on the emergence and dynamics of E-M heterogeneity in a cell population. However, it remains unclear how different intra- and inter-cellular processes shape the dynamics of E-M heterogeneity. Here, using Cell Population Balance model, we capture the dynamics of cell density along E-M phenotypic axis resulting from interplay between-(a) intracellular regulatory interaction among biomolecules, (b) cell division and death and (c) stochastic cell-state transition. We find that while the existence of E-M heterogeneity depends on intracellular regulation, heterogeneity gets enhanced with stochastic cell-stat

SUBMITTER: Guilberteau J 

PROVIDER: S-EPMC11885588 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature