Central amygdala somatostatin neurons modulate stress-induced sleep-onset insomnia.

ABSTRACT: Sleep-onset insomnia, characterized by difficulty falling asleep, is linked to increased health risks. Previous studies have shown that the central amygdala (CeA) plays a crucial role in stress regulation, with the somatostatin neurons in the CeA (CeA^SST+) involved in adaptive stress responses. However, the role of CeA^SST+ neurons in stress-induced sleep-onset insomnia remains unclear. In this study, we found that the activity of CeA^SST+ neurons is closely associated with stressful events using fiber photometry in mice. Acute optogenetic activation of CeA^SST+ neurons induced a rapid transition from non-rapid eye movement (NREM) sleep to wakefulness. Semi-chronic optogenetic and chemogenetic activation of CeA^SST+ neurons led to prolonge

SUBMITTER: Yao W 

PROVIDER: S-EPMC11885604 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature