Identification of potential susceptibility loci for non-small cell lung cancer through whole genome sequencing in circadian rhythm genes.

ABSTRACT: Lung cancer is a malignant tumor with a high morbidity and mortality rate worldwide, causing an increasing disease burden. Of these, the most common type is non-small cell lung cancer (NSCLC), which accounts for 80-85% of all lung cancer cases. Genetic research is crucial for continuously discovering susceptibility genes related to lung cancer for in-depth study. The role of genetic predisposition in the development of NSCLC, particularly within circadian rhythm pathways known to govern various physiological processes, is increasingly acknowledged. Yet, the association between genetic variants of circadian rhythm-related genes and NSCLC susceptibility among Chinese populations is not fully understood. This study carried out a two-phase (discovery and validation stages) research design to i

SUBMITTER: Xu X 

PROVIDER: S-EPMC11885630 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature