Neurophysiological insights into catecholamine-dependent tDCS modulation of cognitive control.

ABSTRACT: Goal-directed behavior requires resolving both consciously and subconsciously induced response conflicts. Neuronal gain control, which enhances processing efficacy, is crucial for conflict resolution and can be increased through pharmacological or brain stimulation interventions, though it faces inherent physical limits. This study examined the effects of anodal transcranial direct current stimulation (atDCS) and methylphenidate (MPH) on conflict processing. Healthy adults (n = 105) performed a flanker task, with electroencephalography (EEG) used to assess alpha and theta band activity (ABA, TBA). Results showed that combining atDCS with MPH enhanced cognitive control and reduced response conflicts more effectively than atDCS alone, particularly when both conflict types co-occurred. Both a

SUBMITTER: Koyun AH 

PROVIDER: S-EPMC11885824 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature