Oral microbiome diversity associates with carotid intima media thickness in middle-aged male subjects.

ABSTRACT:

Background

Although there have been significant advancements in reducing the burden of cardiovascular disease (CVD) by modifying traditional CVD risk factors, substantial risks persist, particularly among male subjects who exhibit heightened susceptibility to atherosclerosis. In this context, we aim to study the link between oral microbiome and carotid intima media thickness (cIMT).

Methods

The Northern Finland Birth Cohort of 1966 (mean age 46 years, n = 869) underwent an extensive health examination, including the measurement of cIMT. The oral microbiome was also investigated using high-throughput 16S rRNA gene sequencing.

Results

Here we show that oral microbiome diversity links with atherosclerosis risk factors, namely smoking, glycemic balance, low-grade inflamma

SUBMITTER: Akhi R 

PROVIDER: S-EPMC11885836 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature