Microglial Activation Visualized by [¹⁸F]-DPA714 PET Is a Potential Marker of Severity and Prognosis for Anti-LGI1 Encephalitis.

ABSTRACT:

Background and purpose

Whether microglial activation plays an important role in the pathogenesis of autoimmune encephalitis (AE), such as anti-leucine-rich, glioma-inactivated-1 (LGI1) encephalitis, remains unknown. [¹⁸F]-DPA714 PET targeting the translocator protein (TSPO) is a novel method to detect neuroinflammation via visualizing activated microglia. In this study, we aimed to investigate the application of [¹⁸F]-DPA714 PET in anti-LGI1 encephalitis.

Methods

Patients with anti-LGI1 encephalitis and non-inflammatory controls (NIC) underwent [¹⁸F]-DPA714 PET scans were enrolled. Standardized uptake value ratios normalized to the cerebellum (SUVRc) in LGI1-AE patients were calculated for semi-quantitative analysis. The microglial activation

SUBMITTER: Wang J 

PROVIDER: S-EPMC11886409 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature