A Comparative Study of 141 Glial Fibrillary Acidic Protein Immunoglobulin G Positive Cases.

ABSTRACT:

Background

Glial fibrillary acidic protein-immunoglobulin G (GFAP-IgG) positivity is associated with autoimmune GFAP astrocytopathy (GFAP-A), but also with other autoimmune encephalitides and viral infections. We attempted to elucidate the characteristics of GFAP-A in relation to other GFAP-IgG-positive encephalitides and constructed a differential diagnosis model.

Methods

141 GFAP-IgG-positive cases were identified, including 52 astrocytopathy (GFAP-A group), 48 autoimmune encephalitis (AE-G), and 41 viral encephalitis (VE-G). Multivariate logistic regression was employed to create a diagnostic model, with validation using an external cohort.

Result

Compared to the AE-G group, the GFAP-A patients showed more onset age ≥ 50 years, headache, fever, consciousness distur

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11886414 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature