Integrated Analysis to Reveal Heterogeneity of Tumor-Associated Neutrophils in Glioma.

ABSTRACT:

Background

Glioma, characterized by its cellular and molecular heterogeneity, presents formidable challenges in treatment strategy and prognostic assessment. The tumor microenvironment (TME) profoundly influences tumor behavior and treatment response, with tumor-associated neutrophils (TANs) playing a complex but understudied role. This study aimed to investigate the heterogeneity and role of TANs in glioma and to develop a prognostic model.

Methods

Analysis of scRNA-seq data identified cellular subpopulations and differentially expressed neutrophil-related genes (DE-NRGs). Bulk RNA-seq was obtained from four independent datasets. Molecular subtypes of glioma samples were determined by consensus clustering. WGCNA was conducted to elucidate the association between gene module

SUBMITTER: Wang W 

PROVIDER: S-EPMC11886415 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature