Mixture Effects of Polystyrene Microplastics on the Gut Microbiota in C57BL/6 Mice.

ABSTRACT: Microplastics are plastic particles with sizes of less than 5 mm. The ubiquity of microplastics in the environment has raised serious public health concerns. Microplastics could disturb the composition of the gut microbiota due to both chemical composition and physical interactions, which might further influence the metabolism and immune function of the host. However, most of the exposure studies chose microplastics of specific sizes. In the natural environment, living organisms are exposed to a mixture of microplastics of various sizes. In this study, male C57BL/6 mice were exposed to polystyrene (PS) microplastics with different sizes, including microplastics with diameters of 0.05-0.1 μm (PS0.1 group, 100 ppb), 9-10 μm (PS10 group, 100 ppb), and microplastic mixtures of both 0.05-0.1 an

SUBMITTER: Gao B 

PROVIDER: S-EPMC11886427 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature