Evaluation of In Silico and In Vitro Antidiabetic Properties of 4-(Hydroxysubstituted Arylidene)-2-Phenyloxazol-5(4<i>H</i>)-one Derivatives.

ABSTRACT: Oxazolones are heterocyclic molecules characterized by a five-membered ring containing both nitrogen and oxygen atoms. It is a significant pharmacophore for therapies as well as a synthon for many physiologically active compounds. Since diabetes is a chronic disease that affects how the body metabolizes sugars, the major focus of this study was to evaluate the antidiabetic properties of synthetic 4-( Hydroxysubstituted arylidene)-2-phenyloxazol-5(4 H )-one derivatives in silico and in vitro. Derivatives were synthesized by the Erlenmeyer and Justus method with slight modifications. Structures of the derivatives were confirmed by physical, FTIR, ¹H NMR, ¹³C NMR, and HRMS data. Mainly, the antidiabetic properties were determined via α-

SUBMITTER: Jayasinghe RN 

PROVIDER: S-EPMC11886645 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature