Fish Gelatin-Hyaluronic Acid Scaffold for Construction of an Artificial Three-Dimensional Skin Model.

ABSTRACT: Artificial three-dimensional (3D) skin models have been used as an alternative tool for toxicity testing, skin disease studying, and skin tissue engineering. The 3D skin model can be fabricated using a porous scaffold that provides 3D cellular construction that supports cell attachment and promotes nutrient and air permeation. In this study, fish gelatin (FG) and hyaluronic acid (HA) were selected for scaffold fabrication because they carry no risk of zoonotic disease transmission and are major components of the extracellular matrix (ECM), which may functionally mimic the ECM of native human skin. The FG-HA scaffolds prepared by using a freeze-drying technique were characterized for their porosity, swelling ratio, and mechanical properties. The scaffolds were seeded with dermal fibroblasts

SUBMITTER: Chailom P 

PROVIDER: S-EPMC11886714 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature