Dual Cross-Linked Chitosan-Based Films with pH-Sensitive Coloration and Drug Release Kinetics for Smart Wound Dressings.

ABSTRACT: In this study, we developed dual-cross-linked hydrogel films based on carboxyethyl chitosan (CECS) and sodium alginate (SA), utilizing dialdehyde β-cyclodextrin (DA-βCD) and gluconic acid δ-lactone (GDL) as cross-linkers. Designed as smart wound dressings, the films exhibit pH sensitivity due to the incorporation of carboxyethylated phenol red-grafted chitosan (CS-PR-AA), which allows them to change color from orange to purple in response to pH variations. FT-IR and TGA analyses confirmed the formation of imine bonds and polyelectrolyte complexes, indicating successful cross-linking. The films demonstrated high cell viability, confirming their biocompatibility and nontoxicity. The swelling behavior varied with pH, underscoring their adaptability to different wound environments. Additionall

SUBMITTER: Chalitangkoon J 

PROVIDER: S-EPMC11886715 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature