Unveiling Natural Power: Morin and Myricetin as Potent Inhibitors of Histidinol-Phosphate Aminotransferase in Drug-Resistant <i>Acinetobacter baumannii</i>.

ABSTRACT: The emergence of multidrug-resistant Acinetobacter baumannii poses a significant challenge in healthcare settings, highlighting the urgent need for new therapeutic strategies. This study investigates the inhibition potential of four natural compounds, epicatechin, quercetagetin, myricetin, and morin, against histidinol-phosphate aminotransferase (HPA), a key enzyme in the histidine biosynthesis pathway of A. baumannii. A comprehensive approach combining in silico simulations and experimental techniques was used to assess the efficacy of these compounds. The docking score for myricetin was -8.616 kcal/mol, while for morin, it was -8.082 kcal/mol. The in vitro results examined real-time binding interactions. Experimental validation using surface plasmon resonance

SUBMITTER: Singh A 

PROVIDER: S-EPMC11886752 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature