TiltRec: an ultra-fast and open-source toolkit for cryo-electron tomographic reconstruction.

ABSTRACT:

Motivation

Cryo-electron tomography (cryo-ET) has revolutionized our ability to observe structures from the subcellular to the atomic level in their native states. Achieving high-resolution reconstruction involves collecting tilt series at different angles and subsequently backprojecting them into 3D space or iteratively reconstructing them to build a 3D volume of the specimen. However, the intricate computational demands of tomographic reconstruction pose significant challenges, requiring extensive calculation times that hinder efficiency, especially with large and complex datasets.

Results

We present TiltRec, an open-source toolkit that leverages the parallel capabilities of Central Processing Units and Graphics Processing Units to enhance tomographic reconstruction. TiltR

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC11886794 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature