Postoperative Radiation With or Without Concurrent Chemotherapy for Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma With Multiple Intermediate Risks: A Propensity Score-Matched Study.

ABSTRACT:

Background

The benefit of postoperative chemoradiotherapy (CRT) over radiotherapy (RT) alone remains unclear for resected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) patients with intermediate risk(s) such as pT3 or pT4 primary, pN2 or pN3 nodal disease, nodal disease in levels IV or V, perineural invasion (PNI), and lymphovascular invasion (LVI). This study aims to evaluate the benefits of postoperative CRT in patients with multiple intermediate risks.

Method

LA-HNSCC patients who underwent curative surgery with intermediate risk at our institution were identified. A propensity score-matched (PSM) method was performed using treatment, sex, age, AJCC staging, LVI, and PNI as covariates.

Result

A total of 162 eligible patients were identified. Aft

SUBMITTER: Leewiboonsilp T 

PROVIDER: S-EPMC11886883 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature