Visual-somatosensory integration as a novel behavioral marker of amyloid pathology.

ABSTRACT:

Introduction

The ability to integrate information across sensory modalities is a vital aspect of everyday functioning and is linked to cognition. Increasing evidence suggests that Alzheimer's disease (AD) pathology manifests in sensory association areas before appearing in higher-order cognitive areas. We examined the role of visual-somatosensory integration (VSI) as a novel behavioral marker of AD-associated amyloid pathology.

Methods

This cross-sectional study included 243 adults (77 ± 6.5 years; 52% female) who completed the VSI test and AD biomarker assays. The magnitude of VSI was the independent variable and amyloid-beta probability scores (APS; PrecivityAD^TM) were the dependent variable. Cognitive status (normal, mild cognitive impairment, or AD) was assign

SUBMITTER: Mahoney JR 

PROVIDER: S-EPMC11886890 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature