Micellar HPLC and UV Methods with Time Programming for Synchronically Quantifying Gatifloxacin and Its Preservative in Eye Drops: Appraisal of Ecological Impact.

ABSTRACT: Modern society is increasingly reliant on sustainable solutions. We suggest a creative study that meets the standards of sustainability in analytical chemistry. The objective is to promote eco-friendly methods for concurrently detecting Gatifloxacin (GAT) and benzalkonium chloride (BEN) in ocular solutions. Using a sustained mobile phase flow rate of 0.8 mL/min^-1 and acidic water: 10% 1-butanol in water (40:60, v/v), GAT was retained for 2.242 min at 287 nm, followed by BEN homologues at 215 nm for the next 2.982 and 4.201 min. This process was simple, quick, and precise. The method demonstrated peak symmetry, low processing times, good resolution, and correlation values 0.999. For GAT, the linearity ranged from 0.001 to 0.023 mgmL^-1, while for BEN, it was from 0.003

SUBMITTER: Alwaili MA 

PROVIDER: S-EPMC11886916 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature