Host metabolism balances microbial regulation of bile acid signalling.

ABSTRACT: Metabolites derived from the intestinal microbiota, including bile acids (BA), extensively modulate vertebrate physiology, including development¹, metabolism^2-4, immune responses^5-7 and cognitive function⁸. However, to what extent host responses balance the physiological effects of microbiota-derived metabolites remains unclear^9,10. Here, using untargeted metabolomics of mouse tissues, we identified a family of BA-methylcysteamine (BA-MCY) conjugates that are abundant in the intestine and dependent on vanin 1 (VNN1), a pantetheinase highly expressed in intestinal tissues. This host-dependent MCY conjugation inverts BA function in the hepatobiliary system. Whereas microbiota-derived free BAs function as agonists of the farnesoid X recep

SUBMITTER: Won TH 

PROVIDER: S-EPMC11886927 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature