The Impact of Heart Rate Reduction From Individual Baseline With Propranolol for Primary and Secondary Prophylaxis of Variceal Hemorrhage in Cirrhosis.

ABSTRACT: A target heart rate of 55-60 beats per minute is a goal for propranolol in both primary and secondary prophylaxis of variceal hemorrhage (VH). However, dose adjustments are often needed based on baseline heart rates. This study analyzed the effect of heart rate reduction from baseline with propranolol therapy on VH in patients with cirrhosis. A retrospective study was conducted on cirrhotic patients receiving propranolol for primary and secondary prophylaxis, 2008-2023. Patients were categorized as responders or non-responders based on the achievement of a heart rate reduction of ≥ 25% from baseline. The primary outcome was the incidence of VH. A survival analysis with propensity score-inverse probability treatment weighting was performed to associate heart rate reduction and the outcome.

SUBMITTER: Mingpun W 

PROVIDER: S-EPMC11886985 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature