Photoactivated Multivariate Metal-Organic Frameworks for On-Demand Drug Release: The Role of Host-Guest Interactions.

ABSTRACT: The development of smart drug delivery vehicles capable of controlled release upon application of an external stimulus is of paramount interest for the next generation of personalized medicine. Herein, we report a series of six multivariate (MTV) MOFs capable of visible light-activated drug delivery. The drug loading capacity and release rates were systematically tuned through variation of the linker ratio between 4,4'-azobenzene dicarboxylic acid (H₂ABDA) and 4,4'-(diazene-1,2-diyl)bis(3,5-difluorobenzoic acid) (H₂ABDA(3,5-F)). The drug loading capacity, dictated by host-guest interactions, was thoroughly explored via a combined experimental and computational approach using two model drug or drug-like molecules, 5-fluorouracil (5-FU) and Nile Red. Notably, the loadin

SUBMITTER: Cornell HD 

PROVIDER: S-EPMC11887053 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature