Multimodal Precise Control Over Multiselective Carbonylation of 1,3-Enynes.

ABSTRACT: Efficiently constructing structurally diverse and complex organic molecules through selective catalytic functionalization is a central goal in synthetic chemistry, yet achieving precise control over multiple reactive centers in multisite substrates remains a formidable challenge. Building on foundational advances in single- and dual-selective transformations, we report a multimodal strategy for the selective carbonylation of 1,3-enynes, a versatile class of multisite substrates. Through meticulous fine-tuning of the catalytic conditions, our approach enables five distinct regio- and stereoselective carbonylative transformations, including direct functionalization (1,2- and 2,1-hydroaminocarbonylation) and tandem cyclization pathways (2,4-, 1,3-, and 2,3-carbonylation). Furthermore, mechani

SUBMITTER: Kuai CS 

PROVIDER: S-EPMC11887062 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature