Association of obesity and LDL subfractions evaluated by body mass index, waist circumference, and diabetes status: the ELSA-Brasil study.

ABSTRACT: Low-density lipoproteins (LDL) comprise a pool of particles with different densities that may have variable impact on atherogenesis. Studies suggest that obese individuals with elevated body mass index (BMI) and waist circumference (WC) have increased small and dense LDL subfractions (sdLDL-c). It is unclear if diabetes (T2D) and insulin resistance (IR) may modify this association. We included 4,111 (50.4 ± 8.6 years of age, 45.5% men) individuals with neither prior cardiovascular disease nor use of lipid-lowering medications. Total LDL-c and its subfractions (LDL₁-c, LDL₂-c, LDL₃-c, and LDL₄-c) were measured by vertical zonal ultracentrifugation. We considered the subfractions LDL₁-c and LDL₂-c as large buoyant LDL (lbLDL-c

SUBMITTER: Moraes EG 

PROVIDER: S-EPMC11887076 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature