Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988-2015).

ABSTRACT:

Background

Incidence of childhood Ewing sarcoma, a rare cancer affecting bones and soft tissues, is increasing. Environmental exposures during the perinatal period, like air pollution, may play a role. We examined exposure to perinatal ambient fine particulate matter (PM_2.5) and childhood Ewing sarcoma risk in a case-control linkage study nested within a California birth cohort.

Methods

The study included 388 children born in California (1982-2015) and diagnosed with Ewing sarcoma at age 0-19 years (1988-2015), and 19,341 California-born cancer-free controls frequency-matched to cases on birth year (50:1 ratio). Ambient PM_2.5 concentrations at the maternal residence were averaged separately over two time periods, gestation and the first year after birth

SUBMITTER: Clark CJ 

PROVIDER: S-EPMC11887085 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature