Valproic acid levels in neurodevelopmental disorders: correlation with CYP and SULT genes using LC-MS/MS.

ABSTRACT:

Background

Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs worldwide, which is used to treat migraines, bipolar disorder, and anxiety. However, VPA is associated with a wide range of side effects. This study evaluates therapeutic drug monitoring (TDM) in individuals with neurodevelopmental disorders. It explores the correlation between valproic acid (VPA) plasma levels and genetic polymorphisms in cytochrome P450 (CYP) enzymes and cytosolic sulfotransferase (SULT) genes.

Methods

A simple and accurate LC-MS/MS method was developed, validated, and applied in the TDM of 14 individuals on VPA therapy. Plasma VPA levels were measured, and genotyped genes SULT1A1, CYP2D64, CYP2D610, CYP3A5, and CYP2C19*2. Statistical analyses were conducted using SPSS.

SUBMITTER: Abutaleb S 

PROVIDER: S-EPMC11887086 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature