Merging metabolomics and genomics provides a catalog of genetic factors that influence molecular phenotypes in pigs linking relevant metabolic pathways.

ABSTRACT:

Background

Metabolomics opens novel avenues to study the basic biological mechanisms underlying complex traits, starting from characterization of metabolites. Metabolites and their levels in a biofluid represent simple molecular phenotypes (metabotypes) that are direct products of enzyme activities and relate to all metabolic pathways, including catabolism and anabolism of nutrients. In this study, we demonstrated the utility of merging metabolomics and genomics in pigs to uncover a large list of genetic factors that influence mammalian metabolism.

Results

We obtained targeted characterization of the plasma metabolome of more than 1300 pigs from two populations of Large White and Duroc pig breeds. The metabolomic profiles of these pigs were used to identify genetically influ

SUBMITTER: Bovo S 

PROVIDER: S-EPMC11887101 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature