A survey weighted analysis of HPTN 071 (PopART) primary outcome of HIV incidence.

ABSTRACT:

Introduction

HPTN 071 (PopART) implemented a comprehensive HIV prevention package which aimed to reduce HIV incidence within 21 communities of Zambia and South Africa: Arm A, PopART intervention of universal HIV testing and treatment; Arm B, PopART intervention of universal HIV testing with ART provided according to local guidelines; and Arm C, standard of care. Analyses so far have not accounted for the sampling design of the enrolled cohort. We performed a sample-weighted re-analysis of the primary outcome of the PopART trial to derive a population-based estimate of the intervention effect.

Methods

Enrollment used a two-stage sampling design: household and adult participant within each household. We constructed post-stratification weights to match the age and sex distribut

SUBMITTER: Skalland TM 

PROVIDER: S-EPMC11887120 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature