Glucose reduced nano-Se mitigates Cu-induced ROS by upregulating antioxidant genes in zebrafish larvae.

ABSTRACT: This study compares the therapeutic efficiency of bovine serum albumin-stabilized selenium nanoparticles in reducing oxidative stress and improving cellular health. The nanoparticles were synthesized using mussel-extracted selenium with two reducing agents: d-glucose and orange. Inductively coupled plasma-optical emission spectroscopy and X-ray diffraction analyses confirmed the presence of selenium. The reducing agent and duration influenced the nanoparticle size. Reduction with d-glucose for 1 hour revealed that the particles exhibited an average size of 10 nm. Copper sulfate-induced malformations such as yolk sac and pericardial edema were observed with 25 μg ml^-1 of orange-reduced nanoparticles, while d-glucose-reduced nanoparticles mitigated these malformations at 25 μg ml<

SUBMITTER: Umapathy S 

PROVIDER: S-EPMC11887129 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature