Fecal microbiota transplantation restores gut microbiota diversity in children with active Crohn's disease: a prospective trial.

ABSTRACT:

Background

Clinical data on oral fecal microbiota transplantation (FMT), a promising therapy for Crohn's disease (CD), are limited. Herein, we determined the short-term safety and feasibility of FMT for pediatric patients with active CD.

Methods

In this open-label, parallel-group, single-center prospective trial, patients with active CD were treated with oral FMT capsules combined with partial enteral nutrition (PEN) (80%). The control group comprised pediatric patients with active CD treated with PEN (80%) and immunosuppressants. Thirty-three patients (11.6 ± 1.82 years)-17 in the capsule and 16 in the control groups-were analyzed. Data regarding the adverse events, clinical reactions, intestinal microbiome composition, and biomarker parameters were collected and compared p

SUBMITTER: Zou B 

PROVIDER: S-EPMC11887145 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature