Comparison of the efficacy and safety of docetaxel plus capecitabine versus docetaxel plus epirubicin for human epidermal growth factor 2 -negative breast cancer: a meta-analysis.

ABSTRACT:

Background

This study aimed to evaluate the efficacy and safety of docetaxel plus capecitabine (TX) and docetaxel plus epirubicin (TE) in the treatment of human epidermal growth factor 2 (HER2)-negative breast cancer.

Methods

Relevant studies assessing the efficacy and safety of TX versus TE were systematically searched from PubMed, Cochrane Library, Embase, and Web of Science databases until February 6, 2025. Progression-free survival (PFS), and clinical response, including the overall response rate (ORR), disease control rate (DCR), and grade 3/4 adverse events were compared.

Results

Four articles with moderate methodological quality were included. The pooled results revealed no significant differences in PFS (hazard ratio [HR] (95% confidence interval CI) = 0.86 (0

SUBMITTER: Wu J 

PROVIDER: S-EPMC11887160 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature