CNPY3's regulation of tumor microenvironment and its impact on colon cancer aggressiveness.

ABSTRACT:

Background

Canopy FGF signaling regulator 3 (CNPY3) has been implicated in tumor progression. However, its specific role in colon cancer (CC) remains unclear. This study aims to investigate the function of CNPY3 in CC and its potential as a therapeutic target.

Methods

A total of 201 CC tissue specimens and 67 adjacent non-cancerous tissues were collected for analysis. CNPY3 expression was assessed using immunohistochemistry and quantitative real-time PCR. Functional assays were conducted in CC cell lines (HT-29 and SW-620) following CNPY3 knockdown to evaluate its effects on cell proliferation, migration, and apoptosis. Gene expression profiling, fibroblast co-culture experiments, and in vivo xenograft models were also conducted.

Results

Increased CNPY3 expression cor

SUBMITTER: Gao X 

PROVIDER: S-EPMC11887163 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature