Effect of lid-wiper epitheliopathy on the corneal epithelial thickness distribution: a novel semiautomatic quantitative method.

ABSTRACT:

Background

To explore a novel semi-automatic quantitative method for detecting lid-wiper epitheliopathy (LWE) and analyze its impact on the distribution of corneal epithelial thickness (CET).

Methods

A total of 37 eyes from 37 adults were included in this study. The lid wipers were stained with lissamine green strips, and the stained areas were recorded using a digital slit-lamp biomicroscopy and analyzed using ImageJ software. Factors such as age, sex, and refraction were included as variables that influenced LWE. The CET was divided into 25 regions and recorded using spectral-domain optical coherence tomography.

Results

Methodological consistency and repeatability were verified through intra- and inter-operator intraclass correlation coefficients, with values of 0.8

SUBMITTER: Ye J 

PROVIDER: S-EPMC11887165 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature