PM_2.5 constituent exposures and maternal circulatory homocysteine in early pregnancy.

ABSTRACT:

Background

Elevated homocysteine (Hcy) is a pathogenic mechanism of adverse pregnancy outcomes and PM_2.5-induced cardiovascular diseases. We investigated the associations of fine particulate matter (PM_2.5) and chemical constituent exposures with maternal circulatory Hcy in early pregnancy.

Methods

Serum Hcy and 5-methyltetrahydrofolate in 324 women with pregnancy (162 normal early pregnancy [NEP] and 162 early pregnancy loss [EPL]) were measured by ultra-performance liquid chromatography-tandem triple quadrupole mass spectrometry. Daily exposures to PM_2.5 and constituents (black carbon [BC], organic matter, nitrate, ammonium, and sulfate) were accessed using data of Tracking Air Pollution in China platform. Nonlinear and linear associations o

SUBMITTER: Li X 

PROVIDER: S-EPMC11887181 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature