Elevated prolactin levels before endometrial transformation negatively impact reproductive outcomes in frozen embryo transfer cycles under hormone replacement therapy.

ABSTRACT:

Introduction

Prolactin (PRL) plays a key role in the regulation of reproductive functions. However, its impact on outcomes in infertility women undergoing assisted reproductive technology remains unclear. This study aimed to examine the relationship between PRL levels and reproductive outcomes in frozen embryo transfer (FET) cycles under hormone replacement therapy (HRT).

Materials and methods

A total of 1212 FET cycles under HRT were included from a single center in Shanghai between March 2013 and June 2023. PRL levels were measured on the day before progesterone-induced endometrial transformation and participants were stratified according to the near-quartiles cut-points of PRL. Logistic regression analyses were performed to assess the associations between different PRL le

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11887199 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature