GoldPolish-target: targeted long-read genome assembly polishing.

ABSTRACT:

Background

Advanced long-read sequencing technologies, such as those from Oxford Nanopore Technologies and Pacific Biosciences, are finding a wide use in de novo genome sequencing projects. However, long reads typically have higher error rates relative to short reads. If left unaddressed, subsequent genome assemblies may exhibit high base error rates that compromise the reliability of downstream analysis. Several specialized error correction tools for genome assemblies have since emerged, employing a range of algorithms and strategies to improve base quality. However, despite these efforts, many genome assembly workflows still produce regions with elevated error rates, such as gaps filled with unpolished or ambiguous bases. To address this, we introduce GoldPolish-Target, a modular

SUBMITTER: Zhang E 

PROVIDER: S-EPMC11887200 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature