A novel immunoinformatic approach for design and evaluation of heptavalent multiepitope foot-and-mouth disease virus vaccine.

ABSTRACT:

Background

Foot-and-mouth disease virus (FMDV) vaccine development can be a laborious task due to the existence of various serotypes and lineages and its quasi-species nature. Immunoinformatics provide effective and promising avenue for the development of multiepitope vaccines against such complex pathogens. In this study, we developed an immunoinformatic pipeline to design a heptavalent multi-epitope vaccine targeting circulating FMDV isolates in Egypt.

Result

B and T-cell epitopes were predicted and selected epitopes were proved to be non-allergenic, non-toxic, with high antigenicity, and able to induce interferon-gamma response. The epitopes were used to construct a vaccine by adding suitable linkers and adjuvant. Prediction, refinement, and validation of the final constr

SUBMITTER: Zaher MR 

PROVIDER: S-EPMC11887215 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature